The Science Behind Lowering Oxidative Stress (Chronic Inflammation)

The Science Behind ROOT Cause Supplements

Dr. J. Miller D.O., FACOG

Our Immune System is very dynamic involving many areas of the body and many cells, with a diverse range of functions and activity. Our Immune Cells are trained to respond to areas of bodily injury and foreign compounds which become internalized, most commonly by our digestive system or respiratory system. The Immune system involves many different cell lines, and areas of the body, with early responding cells and late responders, and the production of antibodies. Immuno-Therapy has become mainstream for the treatment of many disorders, and The ROOT Cause of developing pathology is INFLAMMATION.

In the Initial phase of Injury, or response to exposure to a foreign agent, our Immune cells cause a healthy inflammatory response at the site of injury or exposure, and lessen the risk of infection, along with promoting a proper healing response, and attempts to destroy or wall off the foreign agent. However, in some instances the Immune Response can turn into a chronic response, promoting an unhealthy Inflammatory response, as in prolonged viral syndromes, or auto-immune disorders, resulting in Immune System Dysregulation.

When we discuss the unhealthy effects of chronic inflammation on our cells and tissues, the above references (Viral syndromes & Auto-Immune disorders), are 2 of many mechanisms, specifically related to our Immune System, contributing to our everyday cellular chronic inflammation (oxidative stress).

Our normal physiology and daily biochemical reactions produce a daily baseline load of free-radicals, and thus oxidative stress (chronic Inflammation), by a daily cascade of normal biochemical reactions required to run our body, causing the production of these free-radicals. This is another example of other Inflammation, not directly related to our Immune System.

Everyone has a different baseline load of oxidative stress (chronic Inflammation), depending on their environment, type of foods Ingested, genetics, medical conditions, smoking, alcohol use, emotional stress, workplace environment, and many other contributing factors.

Oxidative Stress on our Cells, Tissues & Organs = Chronic Inflammation = From production of free-radicals. Oxidative Stress is a biochemical stress, imposed upon our cells from free-radicals, not emotional stress. However, elevated emotional stress can cause increased Oxidative stress upon our cells.

A proven scientific fact is Energy cannot be created or destroyed, thus being the First Law of Thermodynamics. A specific, and basic example contributing to our Oxidative Stress would be: when our body uses food as a source for fuel, our body performs its biochemical reactions via extracting energy from the food, and the by-products of theses biochemical reactions yields molecules with one less electron – This is the free-radical; a molecule having one less electron, as the energy used to process your food, to be utilized as energy by your cells, is lost in these molecules, as energy cannot be created or destroyed; thus if energy is taken on one side of the equation, to be used as energy from the food we ingest, it must be lost on the other side of the equation, which is the molecule with one less electron, thus the free-radical.

It is these molecules with one unpaired electron (free-radicals), that act erratically, damaging nearby normal cells, creating a constant daily baseline load of oxidative stress (chronic Inflammation). We must suppress this oxidative stress significantly, on a daily basis, to keep a healthy environment on the cellular level; as this chronic inflammation, from these free-radicals, is what causes damage to our cells, tissues and organs, ultimately leading to illness in one form or another, and is also the ROOT Cause of Aging.

Ingesting Healthy and significant quantities of plant-based agents in our diet, and in the form of supplements, is the best way to combat this oxidative stress (chronic inflammation), caused by 2 Main Mechanisms: The Immune System and Free-Radicals.

The above example (processing our food) is 1 of Thousands of examples that create these biochemical reactions in our body to cause oxidative stress (chronic Inflammation). In the above example, we referenced how processing our food leads to biochemical reactions, which create free-radicals = oxidative stress = chronic inflammation. The production of free-radicals from eating our food is obviously a factor we cannot control. There are factors we cannot control and factors we can control that cause oxidative stress(chronic inflammation). Non-modifiable are factors we can’t control, and modifiable are factors we can control, that cause oxidative stress (chronic inflammation), inside our body on a cellular level.

We will use the following example to better understand our Baseline Level of Oxidative Stress (Chronic Inflammation). In medicine when we speak of a disorder, we use the terms modifiable and non-modifiable risk factors towards a certain disorder. Using High Cholesterol as an example, a non-modifiable risk factor would be Genetics, and the inheritance of a gene causing familial hypercholesterolemia. Modifiable risk factors on the other hand are things you can control / modify, such as: Diet & Exercise. In either situation, you still have high cholesterol, and it must be addressed.

One can only address the modifiable risk factors pertaining to the disease. However, we always need to address the oxidative stress, both our baseline oxidative stress, and the additional oxidative stress, as a result of the high cholesterol.

The baseline Oxidative Stress (chronic inflammation), free radical damage to our cells caused by everyday biochemical reactions which our body needs to carry out (non-modifiable risk factors towards oxidative stress), to function properly and perform daily roles such as processing of foods and eliminating waste. We all have Oxidative Stress which is OUR BASELINE (Non-Modifiable).

Once we acquire a disease or disorder, our oxidative stress increases over and above our Baseline, with the additional load of oxidative stress from the disease or disorder, and therefore, one must address their oxidative stress (chronic inflammation) more aggressively.

Some individuals fully understand the impact and science of oxidative stress on our cells, and treat their baseline chronic inflammation aggressively, even if they are in great health, as they are focusing on keeping their baseline oxidative stress (chronic inflammation) as low as possible, keeping their cellular functioning as optimal and efficiently as possible, by reducing the burden of free radicals on their cells. This is essentially the ROOT Cause of Preventative Medicine. We can be in good health, and still suffer a heart attack at the age of 68 for example. We all have a Baseline level of oxidative stress (chronic inflammation) which will manifest in our lives at one point or another. Our goal is to push that time as far down the road as possible and improve our quality of life.

The Impact of Oxidative Stress (chronic inflammation) on our cells is exponentially large, which is why no matter how aggressive we are with daily treatment, we will never beat it, and stop aging. However, to make a significant impact on our health, prevention of illness, and improvement of daily quality of life (less arthritis pain, etc.), we must be aggressive in lowering our chronic inflammation (oxidative stress).

Oxidation is a term we are familiar with, an example is when metal rusts. Anti-Inflammatory healthy compounds, and Anti-Oxidants, combat this free-radical cascade on our cells. Anti-Inflammatory / Anti-Oxidants (which are essentially one in the same) ingested daily, reduce the damage done by free-radicals, thus reducing chronic inflammation, allowing our cells to function more efficiently, allowing the inner lining of our arteries and veins to be protected from damage, and resulting arteriosclerosis.

We can discuss/mention how it does the same for other body systems, however, we mention the Cardiovascular system (arteriosclerosis), in the above paragraph, as damage to this system (Cardiovascular), over time is the #1 cause of morbidity and mortality. Thus, we should be diligent in our daily habits to prevent damage to our cardiovascular system. As a population we don’t take nearly enough action to reduce our future risk of cardiovascular disease. The ROOT Cause Being reducing Oxidative Stress (chronic Inflammation) on the inner lining of our arteries and veins.

Please note the Cardiovascular system is not only referring to the Heart. However, as the name implies our vessels to all body organs. Prevention of Stroke, Heart attack and the simple proper delivery of oxygen and nutrients to all our tissues, by maintaining a healthy environment on the inside of our arteries and veins, is crucial to proper and optimal cellular, and thus organ function.

Once again, cardiovascular disease is the #1 cause of overall morbidity and mortality, and the only agent recommended over the years was / is, aspirin for prevention. Whether taking 1 baby aspirin daily, or 4 baby aspirin (full-strength aspirin), we are making a very small impact on our oxidative stress (chronic inflammation).

Aspirin is still recommended; however, newer studies reveal possible elevated risk of stroke in some individuals, therefore, it is less commonly recommended for primary prevention of Cardiovascular disease. Turmeric / Curcumin and other plant-based compounds, remain superior to aspirin in safety and efficacy, in significantly reducing cardiovascular disease, without elevated risk of stroke. Also, Turmeric / Curcumin, and other plant-based compounds, have a myriad of additional health benefits, not offered by aspirin. One most important is a healthy GI (Gastrointestinal) system, whereas aspirin is unhealthy for the GI mucosa.

Whether taking Aspirin, Turmeric / Curcumin, or most recently approved by the FDA, Colchicine; for Cardiovascular Prevention, and treatment after a cardiac event, each mechanism is the same between all 3 compounds; which is the reduction of inflammation (oxidative stress), and thus inhibiting plaque accumulating within the coronary arteries. The second mechanism shared by all 3 agents is the mild thinning of blood, improving blood flow (circulation).  Colchicine is a medication approved for 20 years to treat Inflammation related to Gout. It has most recently, in August 2023, been approved by the FDA, to lower inflammation for the prevention of cardiovascular disease. Yes, the FDA recognizes that lowering inflammation is important to prevent cardiovascular disease.

When we speak of plaque accumulation in our arteries, yes, we are preventing plaque accumulation in ALL our arteries. Therefore, Why do we always reference the coronary arteries, and not other arteries? Several reasons: 1- other arteries are larger and take longer to accumulate plaque build up to significantly block blood flow. However, there are also arteries smaller than the coronary arteries such as those on the distal branches of our lungs and brain network of vessels, so why are we not discussing those? The Answer: 2- Coronary Arteries are the first set of arteries coming off the Aorta, as it exits the Left Ventricle of the Heart, Therefore, these arteries experience a high pressure / force of blood flow. You have Blood going from the largest artery in the body, the Aorta, with high force/pressure, into a medium sized artery, the coronary arteries, which feed blood to the wall / muscle of the heart. This high force/pressure creates a turbulent shear force on the inner lining of the coronary arteries. This constant shear force damages the endothelial surface of the coronary arteries, quicker than other arteries. The area of damage then elicits a chronic inflammatory process, partially by the immune system as it attempts to repair the area, and partially by normal oxidative stress. This area then becomes more prone to oxidative stress, with an increasing number of risk factors, such as high cholesterol, high blood pressure, diabetes etc.

Just as the Renal arteries feed the kidneys, the Coronary arteries feed the heart. Blockage of any artery will cause the tissue / organ to stop working , or work suboptimal, from necrosis of that tissue. For reasons discussed above, as the Renal arteries are larger, exit the Aorta much further down, with much less pressure and shear force, and thus less risk of damage. This is why we focus on the coronary arteries with respect to cardiovascular disease, and plaque accumulation. They are most vulnerable to damage, and when damaged they cause lack of blood flow to the most important organ for survival, The Heart. However, taking Anti-Inflammatory / Anti-Oxidant agents, improves the inner lining of ALL your arteries.

The ROOT Cause of arteriosclerosis Is Chronic Inflammation (Oxidative Stress). We will all accumulate plaque inside our arteries, some more rapidly than others. Those with genetic risk factors, diabetes, hypertension, significantly elevated cholesterol and triglycerides, Auto-Immune Disorders, Environmental Pollutants, smoking, and many other risk factors, will have an accelerated process; thus, the reason why some individuals have a heart attack or a stroke, and others don’t. Thus, the reason why diabetics, individuals with hypertension, elevated cholesterol, excess emotional stress, Auto-Immune disorders (RA, Lupu, UC, MS etc.), and many other conditions, have accelerated problems with bodily organs such as The Heart, Brain, Intestines, Colon, Liver & Kidneys. These individuals have an accelerated amount of oxidative stress (chronic inflammation), above and beyond our baseline, with our baseline stemming from our regular routine biochemical reactions required by our body, to carry out normal daily functioning.

As discussed previously, we all have our baseline level of oxidative stress (chronic inflammation) from our normal bodily functions and resultant biochemical reactions, which are necessary to carry out these normal bodily functions. However, those with Diabetes for example, have a significantly higher burden of oxidative stress upon their cells, tissues, and organs daily. Therefore, it becomes equally important to address this chronic inflammation, as it is to control blood sugars. There are thousands of disorders which contribute to our cellular burden of oxidative stress (chronic inflammation); however, diabetes is very common, and is also very high on the list, as Diabetes is one of the disorders contributing to our burden of chronic inflammation (oxidative stress) significantly above our baseline, and thus leading to many health-related complications.

With Diabetes, the inability to control your blood sugars is the primary event, however, The ROOT Cause of why diabetics have a much higher degree of Heart attacks, Strokes, and lower extremity amputations, stems from the resultant oxidative stress (chronic inflammation), from the accelerated rate of endothelial cell damage (arteriosclerosis) on the inner lining of arteries. Specifically, the Coronary Arteries with respect to heart attacks, Cerebral circulation with respect to strokes, and lower extremity arteries (circulation) with respect to amputations. Not only is it critical to keep our vessels open to prevent heart attacks, strokes, and poor lower extremity circulation; however, the better your circulation, the more oxygen, nutrients, and minerals you deliver to your cells and tissues; thus, the more optimal they will function, the less they need to compensate over time, and the lower the chance of malfunction over time.

Think of compensation with respect to the functioning of an automobile. If an automobile is maintained well, it will function better and break down less. The more detailed you are about maintaining it, the better it will function, and the less it will compensate and break down over time. Now, there are different levels of maintenance, therefore, if you just change the oil regularly for the first 5 years, and just address baseline maintenance you will have quicker problems with your tires by not rotating them, you will have your brakes eat into your metal disk by not changing them etc.. Just changing the oil is comparable to just trying to control your blood sugars with diabetes, and not addressing other maintenance issues comparable to lowering your chronic inflammation (oxidative stress).

Therefore, by just focusing on Blood Sugar Levels with respect to Diabetes, you are comparably just changing the oil every 5 years, and not addressing other important matters such as the significantly elevated oxidative stress (chronic inflammation) above baseline, due to the diabetes, which is impacting your cells. Therefore, as we mentioned earlier, it is equally important to address all areas of maintenance for the best long-term outcome and prevention of complications. Turmeric / Curcumin, and many other Plant-Based Compounds address both issues simultaneously – Controlling Blood Sugars & equally as important, Lowering Inflammation, as do many plant-based compounds. This does not mean you should stop your diabetic medications. That weaning process is a discussion for another time. Rather, ROOT Cause Supplements, starting with Curcu-Meric 975 mg, perfectly complement your diabetic, blood pressure, cholesterol, thyroid, and other medications. Individuals on blood thinners are instructed to take lower doses of Curcu-Meric 975mg , on a case-by-case basis. Please feel free to email: with any questions.

If you have no medical problems, and are in great physical health, you still have a baseline level of oxidative stress (chronic inflammation) bombarding your cells daily, which needs to be addressed. This is the most significant factor contributing to our aging. Over time this will catch up with your cells, tissues, and organs; much less quickly than if you had diabetes, however, for proper maintenance and prevention of disease it needs to be addressed daily.

You may ask the question: If 2 individuals have the same everything: diet, exercise routine, weight etc.. why do they age differently and develop different complications (i.e. Heart attack, stroke etc.), and why do some develop them at a younger age and others an older age. The answer is: Their baseline level of oxidative stress (chronic inflammation) is different. Their non-modifiable risk factors are different. Many factors as mentioned earlier contribute towards your baseline level of oxidative stress (chronic inflammation); those being genetics, workplace environment, natural outside environment (level of pollution), how you handle emotional and psychological stress, eating and exercise habits (even though we mentioned these 2 hypothetical individuals both have the same diet and exercise) there still will be variability contributing to how well they maintain their baseline level of oxidative stress (chronic inflammation). Some Risk factors are in the middle, semi-modifiable, such as Air Quality (Pollution) & Work Place environment or lifestyle. We will all be exposed to both inevitably, as we need to breathe and we need to work/ function in society, contributing to our oxidative stress (chronic Inflammation), to one degree or another; however, we can choose to make changes by moving to a healthier environment or a healthier job / workplace. Thus, these are examples of semi-modifiable risk factors to long term oxidative stress (chronic inflammation), and future health, as we can make choices to lessen the burden in those areas.

The example pertaining to diabetes can be applied to many thousands of disorders, however, even more severe than just diabetes alone would be Metabolic Syndrome, involving an individual with Glucose Imbalance / Diabetes, elevated cholesterol, increased abdominal fat & high blood pressure. If you are afflicted with 3-4 of these conditions, this is referenced as Metabolic Syndrome, which significantly increases adverse health consequences. Once again, we see The ROOT Cause of adverse health sequelae stems from endothelial cell dysfunction inside the arteries, and the cells that make up the tissue or organ itself, from oxidative stress (chronic inflammation), from an accelerated rate of free-radical damage, resulting in accelerated rate of heart attacks, strokes, kidney failure and amputations; essentially affecting every organ and body system.

We would like to clarify something, the endothelial cells on the inner surface of your arteries and veins are not the ONLY cells affected by oxidative stress (chronic inflammation), as ALL cells are affected (cells that make up the tissue or organ itself). However, damage to the inner lining of your blood vessels will manifest symptoms initially / quicker in majority of cases, and with more severe health problems, which is why cardiovascular health remains our area of focus, and the first area we use as an example.

It is obviously important to keep Blood Pressure controlled, cholesterol at an acceptable level, blood sugar balanced, and weight control addressed. However, this is only half the battle, as it’s equally important to lower your oxidative stress (chronic inflammation) daily. Our Capsules are designed to Control Blood Sugars, Lower Blood Pressure, Lower Cholesterol, Manage Auto-Immune disorders, and address the primary problem, as well as lower whole-body inflammation (oxidative stress). Once again, traditional mainstream medicine is useful and necessary to address your medical problems. Pairing Traditional Medications, with healthy, all-natural compounds to lower your whole-body inflammation (oxidative stress) is extremely important, valuable, and safe. Over time, can traditional medications be lessened with gradual loss of weight, and control over the medical condition? Absolutely, however extremely slowly, and on a case-by -case basis.

We used the example above of Metabolic Syndrome, as that is one of the most detrimental to your health, however, if you are afflicted with only Hypertension, or only a thyroid problem, this still places your baseline load of oxidative stress above a normal level of oxidative stress (chronic Inflammation).

Supplementing your Cells, Tissues and Organs with Vitamins, Minerals, Enzymes & Co-Factors is important, however, what is more important, is to lower your Chronic Inflammation (Oxidative Stress), 1- ON A DAILY BASIS &, 2- TO A SIGNIFICANT DEGREE. Treating the underlying condition and lowering oxidative stress go hand-in-hand, feeding off one another in a vicious cycle of improvement.

A Healthy diet and exercise are important, however, the degree of oxidative stress our body encounters daily is a very large burden. Oxidative Stress is the primary driving force that causes Aging, Disease, and poor quality of life. Ingesting an anti-inflammatory / anti-oxidant rich diet is great, however, is not sufficient to significantly impact our daily load of free-radicals bombarding our tissues. Especially if we factor in disease and illness, which significantly raises the level of oxidative stress above baseline, as with the above examples.

Anti-Oxidants Combat the Oxidative Stress our cells encounter on a daily basis. Thus, the main reason why Fruits and Vegetables are healthy for us. They contain hundreds/thousands of anti-oxidants which combat our oxidative stress. In the past 10-20-30 years our bodies and cells have been bombarded with increasing amounts of Oxidative Stress, due to evolving unhealthy environmental factors, food toxin factors, workplace factors, emotional and psycho-social stress factors, etc.., thus the reason for Immune System Dysregulation, and the rising incidence of Auto-Immune Disorders, Cardiovascular disease, and Endocrine system Dysfunction (i.e. Diabetes etc.). It’s impossible to obtain sufficient levels of anti-oxidants and anti-inflammatory agents on a daily basis, even when eating a healthy well-rounded diet. Supplementing with Organic Plant-Based Botanical Formulas, without any added fillers or preservatives is crucial.

Why are Plant-Based compounds such as Turmeric / Moringa / Ginger etc., more Therapeutic as anti-inflammatory and anti-oxidant agents, compared to synthetic anti-oxidants such as Vitamin C / Vitamin E etc.? 

Taking supplements with synthetic anti-oxidants helps, however, the fact that they are synthetic creates a double edge sword. The best example would be Vitamin C. We do not produce Vitamin C in our body naturally and depend upon external sources. Ingesting Vitamin C in fruits, vegetables, juices etc. is great for purity and maximal absorption by our Gut. Anything we eat or drink gets broken down for our Gut lining to properly absorb. The more natural the source of the agent presented to our Gut lining cells, the easier and more efficiently these cells can absorb these nutrients, minerals, proteins etc.

Therefore, a synthetic Vitamin C (ascorbic acid) is healthy to take as a supplement to your dietary vitamin C intake; However, being synthetic and not from a natural source, there is a lower rate of absorption (from your gut, and delivered to your bloodstream), along with a lower ability to be utilized by your tissues (bioavailability). Also, the synthetic nature of Vitamin C, ascorbic acid, will cause the gut to elicit a small immune response, and a histamine response, causing minimal increase in  inflammation (oxidative stress). Same with respect to any fillers / preservatives included in the capsule / pill. The gut lining cells will manifest a small inflammatory response against these synthetic agents, as it recognizes them as foreign agents.

This is a perfect analogy of how Immuno-Therapy is currently used to treat Cancer. Immuno-Therapy has become a mainstay in treating cancer along with Chemotherapy. The Immune System is utilized by Immuno-Therapy to recognize the cancer cells as foreign, stimulating specific parts of the Immune System to attack the cancer cells, and / or inhibit the growth of the aberrant cells.

We are not stating Vitamin C, ascorbic acid, as an anti-oxidant is not healthy for you as a supplement, however, one is not significantly lowering their oxidative stress to a level that will make a significant clinical impact, with a few thousand milligrams of Vitamin C daily.

Taking a Capsule or tablet of Vitamin C or Vitamin E as an anti-oxidant is ok, however, will never address the burden of free-radicals, causing oxidative stress on our tissues. The chronic inflammation caused by this process needs to be addressed by compounds which not only decrease oxidative stress (anti-oxidants), however, also have a therapeutic healthy anti-inflammatory response, and contain highly absorbable vitamins and minerals to optimize the internal workings of the cell, such as, the mitochondria, nucleus, ribosomes, Golgi Apparatus, cell membrane etc.

The other issue is vitamins such as vitamin C in the form of ascorbic acid are synthetic, and the body recognizes these agents as foreign. Thus, yes there is a small degree of anti-oxidant potential and benefit from taking vitamin C, however, the foreign nature of ascorbic acid causes an abnormal immune response and thus contributes to chronic inflammation.  Thus, Vitamin C and other synthetic vitamins have a small degree of anti-oxidant potential, however, nothing near the potential of Turmeric / Curcumin and other plant-based compounds. Also, instead of acting as an anti-oxidant / anti-inflammatory dual agent like Turmeric / Curcumin, vitamin C causes an increase in the inflammatory response of the immune system as it is recognized as a foreign synthetic agent. Thus, Vitamin C has an anti-oxidant property, however this is partially negated by the Pro-Inflammatory Immune Response.

We want no misunderstanding in using Vitamin C as an example. Anti-oxidants such as Vitamin C, Vitamin E, Vitamin A Supplements, are healthy to ingest, and are beneficial, however, do not address the anti-inflammatory problems, and thus oxidative stress encountered by our cells on a daily basis, as well as a natural plant-based compounds, especially for prevention of cardiovascular disease. This can be applied to all synthetic based vitamins and not just Vitamins C, E. A.

There are many other examples such as NAD, MSM etc., which are synthetic compounds, more so than Vitamin C as ascorbic acid, which have a double edge sword to them. Beneficial in one aspect, however counter-effective in another.

Since we used Vitamin C as an example, it would be appropriate to mention we do use vitamin C as a blend 50/50 Ascorbic Acid and Acerola Cherry in some of our capsule formulas. With our capsules containing several plant-based ingredients in one capsule, and many ingredients between all 10 of our capsules, you receive maximum benefits from synergy with the other ingredients. Also, other plant-based compounds have small amounts of highly absorbable natural vitamin c.


Why choose ROOT Cause Supplements?

Lower Whole-Body Inflammation

Optimize The Cell

Optimize The Immune System

Lower Future Risk of Cardiovascular Disease –

#1 Cause of morbidity / mortality & decreased quality of life

  1. ROOT Cause Supplements are Plant-Based, and therefore, contain the most absorbable forms of vitamins, nutrients, and minerals, besides being extremely therapeutic in Lowering Whole-Body Inflammation & Oxidative Stress (chronic inflammation), via the high level of anti-oxidants and anti-inflammatory compounds.
  2. No matter how pure or strong a capsule is, one needs to ingest sufficient quantities to make a significant impact on their health. Our capsules are safe and effective, as they contain no fillers, preservatives, or anti-caking agents, creating no downside to higher dosing with our supplements.  
  3. Our supplements include a synergistic formula of plant-based anti-inflammatory / anti-oxidant compounds, many of which are not ingested on a regular basis in our daily diet, or are ingested, however, not of sufficient quantities for the desired therapeutic effect. Plant-Based compounds such as Turmeric, Moringa, Ginger, Clove, Spirulina etc., are not synthetic, and provide highly absorbable vitamins and minerals, besides significantly lowering your Inflammation & Oxidative Stress, with therapeutic & clinical results; (lower cholesterol, less auto-immune flares, controlling blood sugars, reducing symptoms of neuropathy, reducing joint pain etc.)
  4. All Plant-Based ingredients in ROOT Cause Supplements are organic, with an abundance of All-Natural highly absorbable vitamins & minerals, without fillers or preservatives. Therefore, An Individual can take higher doses of our supplements, yielding therapeutic clinical benefits in Auto-Immune and other disorders with a high burden of Oxidative stress. Higher dosing is also necessary for plant-based chemo-prevention of carcinoma, as is well documented in the literature.
  5. Plant-Based Ingredients All contribute towards lowering your oxidative stress (chronic Inflammation). All plant-based foods, roots, flowers, barks & spices (and the newer term being used, adaptogens), lower whole-body inflammation by differing mechanisms and degrees.  Some lowering Inflammation more than others, with Turmeric / Curcumin high on the list. However, others such as Moringa & Ginger contribute significantly towards lowering your inflammation in synergy with Turmeric / Curcumin. The other important factor to mention, even though Moringa & Ginger may have less of an anti-inflammatory / anti-oxidant effect in lowering chronic inflammation (oxidative stress); they lower it by differing mechanisms, and provide a different variety of natural vitamins and minerals compared to our reference agents Turmeric / Curcumin. Addressing different mechanisms in lowering inflammation is very important from a clinical perspective, and yields synergistic results when combined with Turmeric / Curcumin. Thus, The reason we recommend pairing 1 or 2 of our other capsules produced at ROOT Cause Supplements, with our Flagship Turmeric / Curcumin Capsule:  Curcu-Meric 975 mgTM
  6. Each Capsule has its own unique synergistic pure therapeutic formula. Synergy is when 2+2=6. The sum results of the total, is greater than the individual components separately. Synergy exists between the ingredients within each capsule, and between all 10 capsules in production.
  7. We follow a No Compromise Policy in sourcing our Raw Ingredients at ROOT Cause Supplements, Fort Lauderdale, FL. We fully guarantee the purity and results of our capsules. If after 3-6 months of using our capsules daily with food or a snack, you do not feel you received any benefits, we will fully provide a refund for your purchases. Obviously, some benefits may take longer to experience results. For Example:


We currently produce 10 Capsules at our Lab in Davie, FL

Hopefully we provided a comprehensive explanation & understanding of the importance of Plant-Based Supplements, containing no fillers or preservatives, with respect to Maximum Absorption & Bioavailability, Lowering Whole-Body Inflammation, Optimizing the Immune System, Preventing Cardiovascular disease & Lessening the Burden of Chronic Inflammation on ALL cells, endothelial (inner lining of arteries & veins), and cells making up the remainder of our tissues and organs.

Any questions may be emailed to:   –  Feel free to ask any health / medical related questions, along with any questions about our supplements.

Our Recommendations on how to take our supplements are strictly related to Therapeutic Results, Prevention of illness & disease, achieving your health goals, and not from a sales perspective. We recommend starting on our Curcu-Meric 975mg Capsule, then pairing 1,2 or 3 of our other capsules with the Curcu-Meric 975mg capsule, the reasoning is based upon achieving significant short and long-term health benefits, improved quality of life, and prevention of disease.

All Capsules Work together with unique synergistic Plant-Based Formulas, Lowering Inflammation by different mechanisms, and providing different vitamins, minerals, co-factors, nutrients & adaptogens for a Comprehensive Regimen.

Taking 2-4 Curcu-Meric 975mg Capsules daily is a perfect starting point. However, if you have significant medical conditions causing elevated oxidative stress (chronic Inflammation) above baseline, it would be recommended to pair 1,2 or 3 other capsules with the Curcu-Meric 975mg Capsule.

There are many benefits to bundling the capsules together, and if you visit the SHOP page on our website through any of the following domains, all leading to the same website: ROOT Cause Supplements-   

On the SHOP page of the website be sure to scroll through ALL pages, and tap on the products or product bundles to read the full explanations, along with recommended dosing regimens.


How did I, Dr. Miller, ROOT Cause Supplements, become interested in researching Inflammation?

How is Inflammation Connected to the Immune System?

Why did we include -Mmune in the name of several of our capsules?

In my studies and research, I was intrigued at the rising prevalence in auto-immune disorders over the past 20 years. I was also intrigued by the simple answer involved in reducing the risk of cardiovascular disease, via reducing whole-body inflammation; along with the lack of education, and of Pure, Plant-based supplements available, which are: non-synthetic, Pure Formulas, no fillers / preservatives, at affordable pricing, focused on this central area of our health.  Also, in the literature, every disorder is somehow tied to oxidative stress (chronic inflammation) on the cellular level.

Over the Past 10 years we have seen a significant increase in Biologics used to treat many Health-Related Disorders, especially Auto-Immune Related disorders such as Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), Ulcerative Colitis (UC).

Biologics are a subset of a class of medications called disease-modifying antirheumatic drugs (DMARDs). Nonbiologic, or conventional, DMARDs, such as methotrexate, are drugs composed of small molecules made from chemicals in a lab. Biologics are large molecules produced in living cells. Both help protect against the effects of inflammation, but in different ways.

Conventional DMARDs suppress the overall immune system, whereas biologics block specific parts of the immune system, such as proteins that promote inflammation. Biologics are more complex and harder to make than conventional DMARDs and cost much more. And unlike small-molecule drugs, they don’t come in pill form. Some are in the form of a self-injection using a prefilled vial and autoinjector. Others are given by intravenous (IV) infusion in a doctor’s office or clinic.

Many people never need biologic DMARDs because conventional DMARDs control their disease well. The American College of Rheumatology recommends methotrexate over a biologic as the first choice for most people with inflammatory autoimmune diseases like rheumatoid arthritis and psoriatic arthritis. If methotrexate or another conventional DMARD isn’t effective, your doctor may switch you to a biologic or a biosimilar, a drug nearly identical to a biologic. Steroids in the form of Prednisone, are also used to suppress the Immune Systems Inflammatory Response, alone or together with Biologics.

Biologics Suppress the Immune System Inflammatory Response, However, does not suppress oxidative stress (chronic inflammation) on a cellular level; Oxidative Stress (chronic inflammation) from both, the auto-immune disorder, and  your baseline oxidative stress (chronic Inflammation), is very important to address, whether receiving Biologics or not.

Biologics have certainly shown some benefit; however, the downside is they suppress the Immune System. Instead of correcting the Immune System Dysregulation, and Optimizing the Immune System, they suppress the Immune System, thus causing other risks and side effects such as Serious Infection, possibly other Auto-Immune disorders, certain Blood based disorders such as lymphoma, leukemia, or myelodysplastic syndrome (MDS). Despite some draw backs, due to suppressing the immune system, Biologics have their role in medicine, however, they need to be used with caution.

This is why our term -Mmune, is used in the Names of some of our specific capsules. To remind our clients / customers ALL our capsules Optimize The Immune System, via suppressing Inflammation, not only Curcu-Meric.  ALL Capsules Produced at ROOT Cause Supplements, Suppress Inflammation, and Optimize The Immune System.  Instead of suppressing the Immune System, as Biologics use this mechanism to Lower your Inflammation. Our Capsules Optimize The Immune System, by correcting Immune System Dysregulation, and / or over-stimulation.

Our Immune System naturally reacts to ALL inflammation in our body as it is meant to perform. Therefore, Via significantly Lowering Inflammation (Oxidative Stress) on a daily basis, with our supplements, starting with our Flagship Capsule, Curcu-Meric 975mg, we lessen the response of our Immune System to “nonsense” irrelevant inflammation, and thus allow the Immune System to perform the important functions it was meant to perform. Thus, our capsules suppress inflammation (oxidative stress), they suppress the excess burden of inflammation on our cells and tissues, and Optimize the Immune system, thus the term -Mmune. To complete the full line of maintenance, ROOT Cause Supplements, also provide our cells with highly bioavailable Plant-based vitamins, minerals, and co-factors, allowing optimal cellular function and efficiency, with less compensation, and less room for error.